Figure 1.

Effect of citrulline (100 µM) on cardiac function under normoxic conditions. (A) Cells were exposed to citrulline for 3 hours and subsequently load-free cell shortening was determined as shortening amplitude normalized to diastolic cell length. Data are means ± SEM from n = 26-30 cells. (B) Hearts were perfused and citrulline was added to the perfusion buffer for 10 minutes. Data are means ± SEM from n = 8 hearts before and after administration of citrulline. LVDP indicates left ventricular developed pressure.

*P < .05 vs control.