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. 2018 Jun 4;215(6):1571–1588. doi: 10.1084/jem.20171450

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© 2018 Pardi et al.

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Figure 10. — mRNA-LNPs provide potent adjuvant activity in a protein subunit vaccine. Mice were immunized with a single i.m. injection of 10 µg of recombinant PR8 HA protein alone or in combination with 30 µg of Luc U- or m1Ψ-mRNA-LNPs. (A and B) Total number of splenic Tfh cells (A) and GC B cells (B) were determined 12 d after immunization. (C) HAI titers were measured 4 wk after immunization. Error bars are SEM. n = 5 mice. Statistical analysis: one-way ANOVA with Bonferroni correction, *, P < 0.05.