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. 2018 Jun 4;215(6):1589–1608. doi: 10.1084/jem.20180246

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© 2018 Kadelka et al.

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Figure 3. — Influence of host, viral and disease parameters on binding antibody responses in the white/B subcohort. (A) The influence of the virus load, CD4 count, viral diversity, length of untreated HIV-1 infection, gender, and transmission route on binding antibody responses was determined by univariable (inner squares) and multivariable (outer squares) linear regression for each IgG subclass and each HIV-1 antigen (n = 2,122). Only significant associations (P < 0.05) are colored, and the Bonferroni-corrected significance threshold (P = 0.00016) is shown in the color map. Color intensity represents the significance level of positive (blue) and negative (red) associations. See Table S3 for detailed regression results. (B–E) Impact of the indicated parameter on the relative IgG1 (black), IgG2 (green), and IgG3 (blue) binding activity, based on the same multivariable linear regression analysis as in A. Error bars depict the 95% confidence intervals. Nonsignificant associations are marked by n.s. and are shown in lighter color shades. * highlights significant associations when using a Bonferroni correction for multiple testing. (B) Impact of viral load per unit increase in log₁₀ viral copy numbers per milliliter of blood. (C) Impact of CD4 cell count per 200 cells/µl decrease in CD4 cell count. (D) Impact of viral diversity per 0.01 increase in pol diversity. (E) Impact of infection length per 1,000 d increase in length of untreated HIV-1 infection.