Figure 5.

Distribution of untreated infection length and set-up of correlation network analyses. (A) Patient selection for the antibody response landscape analyses in Figs. 6 and 7. (B) Distribution of untreated infection length in the white/B subcohort. Colors distinguish early (n = 519) and late (n = 2,243) chronic infection and indicate subcohorts of early and late infection analyzed in Fig. 7. All samples with an untreated infection of >15 yr are grouped together (n = 96). (C) Distribution of untreated infection length in the white/B subcohort in individuals with 3- to 10-yr untreated infection and with no or weak neutralization activity (left; n = 1,341) or potent (broad or elite) neutralization activity (right; n = 95). The two distributions do not differ significantly (p_Mann-Whitney = 0.70). (D) Example of the correlation network analyses shown in Figs. 6 (A–C) and 7 (A–C). The relative binding activities to each antigen and each IgG subclass were compared with all other relative binding activities, as exemplified for IgG1 BG505 trimer binding. (E) Example of the correlation network analysis as conducted in Figs. 6 D and 7 D. Only the correlations between the IgG1 and IgG2 responses of the same antigen were investigated. Correlations for IgG1/IgG3 and IgG2/IgG3 responses were conducted the same way.