Figure 6.

Effects of intracerebroventricular administration of tissue factor specific antibodies on distribution of microspheres and hemorrhage spread following SAH. (I) Differences in hemorrhage spread in representative animals (a) and averaged hemorrhage scores (b), and differences in distribution of fluorescent microspheres (c) and their distribution (d) 1 h after their administration into cisterna magna in representative animals without (n = 7) and with intracerebroventricular injection of IgG (n = 5) or tissue factor antibodies (TF a/b, n = 7) *p = .0021. (II) Effects of intracerebroventricular administration of tissue factor specific antibodies on distribution of microspheres in SHAM operated animals (a) and averaged area of fluorescence distribution on the ventral brain surface (b) 1 h after intracisternal injection in naïve animals (control, n = 7) or in which microspheres injection was preceded (1 h) by intracerebroventricular injection of IgG (n = 4) or tissue factor antibodies (TF a/b, n = 7) *p = 0.001.