Figure 1.

Plasma clearance of (a) ¹²⁵I-Aβ40 increased and (b) ¹²⁵I-Aβ42 clearance decreased in insulin pre-administered B6SJLF1 mice. Graphs depict the plasma pharmacokinetics of ¹²⁵I-Aβ fitted to a two-compartment model. (c) Predicted plasma pharmacokinetic parameters are presented in the table as mean ± S.E. (Aβ40: saline (n = 3), insulin (n = 3); Aβ42: saline (n = 6), insulin (n = 7)). *p < 0.05: Student’s t-test. AUC: area under the curve; Cmax: maximum plasma concentration; CL: plasma clearance.