Figure 5.

Insulin modulates ¹²⁵I-Aβ transcytosis and exocytosis in polarized hCMEC/D3 monolayers. (a) The L-A permeability of (i) ¹²⁵I-Aβ40 and (ii) ¹²⁵I-Aβ42 is presented as mean ± S.D. (n = 6). The A-L permeability of (iii) ¹²⁵I-Aβ40 and (iv) ¹²⁵I-Aβ42 is presented as mean ± S.D. (n = 6). *p < 0.05: Student’s t-test. (b) Exocytosis of (i) ¹²⁵I-Aβ40 (control (n = 4), insulin (n = 4)) and (ii) ¹²⁵I-Aβ42 (control (n = 4), insulin (n = 4)) to the luminal (plasma) side. Exocytosis of (iii) ¹²⁵I-Aβ40 (control (n = 4), insulin (n = 3)) and (iv) ¹²⁵I-Aβ42 (control (n = 4), insulin (n = 4)) to the abluminal (brain) side. Data shown is mean ± S.D. *p < 0.05, **p < 0.01: Student’s t-test.