| Day | 0 | 1 | 2 | 3 | 4 |
|---|---|---|---|---|---|
| Appearance | |||||
| Body weight (g) (score) | 340 (1) | 305 (3) | 320 (2) | 323 (2) | 335 (1) |
| Coat unkempt/piloerection | 1 | 1 | 1 | 1 | 1 |
| Behaviours | |||||
| Gait | 3 | 3 | 3 | 3 | 3 |
| Response to handling | 0 | 0 | 2 | 0 | 0 |
| Total clinical score | 4 | 7 | 8 | 5 | 5 |
| Total neurological score | 15 | 14 | 14 | 10 | 10 |
| Lesion volume (MRI assessment)* | 7% | ||||
| Other observations | Recovered uneventfully from surgery | Moving around incubator (with severe controlateral deficit) | Attempt to reach food with ipsilateral hand |
*
‘Lesion volume’ (assessed using MRI) is included for the investigator to fill in at the end of the study. This data can then be correlated with clinical and behavioural observations to enable further refinement of monitoring, animal care and procedures.