TABLE 1.

Potencies of ANPs in inhibiting 6CF uptake by OAT1 species orthologs from human, cynomolgus monkey, mouse, rat, and dog

Statistical analyses were performed by one-way analysis of variance followed by Dunnett’s multiple comparisons test. N ≥ 2.

Inhibitor	IC50
	Human	Cynomolgus Monkey	Mouse	Rat	Dog
	μM	μM	μM	μM	μM
Adefovir	71 ± 15	220 ± 67*	399 ± 147***	263 ± 66*	181 ± 4
Cidofovir	88 ± 25	181 ± 67	237 ± 69**	245 ± 19**	185 ± 27
Tenofovir	61 ± 14	343 ± 40****	165 ± 27*	153 ± 17	223 ± 64**

^*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.