Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Kinetic parameters of tenofovir uptake rate by OAT1 wild-type transporters and mutants at position 203
| Species | Amino Acid at position 203 or Equivalent Position |
Km |
|---|---|---|
| μM | ||
| Human | S | 72.6 ± 20 |
| Chimpanzee | S | 44.2 ± 1.5 |
| Gorilla | S | 56.0 ± 7.5 |
| Orangutan | S | 79.0 ± 16 |
| Gibbon | S | 65.0 ± 2.4 |
| Galago | S | 84.9 ± 24 |
| cyOAT1 A203S | S | 105 ± 27 |
| Cynomolgus monkey | A | 254 ± 0.1 |
| Squirrel monkey | A | 181 ± 60 |
| Mouse | A | 138 ± 18 |
| Rat | A | 139 ± 7.6 |
| Dog | A | 157 ± 8.8 |
| hOAT1 S203A | A | 216 ± 19 |
S, Serine; A, Alanine.
