TABLE 5.

OAT1-mediated tenofovir transport efficiencies and SUA levels in species with or without functional uricase

*The mean value of SUA was calculated based on reported levels. The range of SUA is included in parenthesis. —, not applicable.

Species	Without Uricase Activity		With Uricase Activity
	SUA*	Tenofovir Transport Efficiency	SUA	Tenofovir Transport Efficiency
	μM	μl/mg/min	μM	μl/mg/min
Human	318 (210–420) (Tan et al., 2016)	63	—	—
Chimpanzee	244 (120–360) (Fanelli and Beyer, 1974)	61	—	—
Gorilla	146 (130–160) (Fanelli and Beyer, 1974)	49	—	—
Orangutan	140 (110–170) (Fanelli and Beyer, 1974)	69	—	—
Gibbon	178 (120–300) (Fanelli and Beyer, 1974)	52	—	—
Cynomolgus monkey	—	—	36 (30–42) (Fanelli and Beyer, 1974)	10
Squirrel monkey	—	—	30 (12–60) (Fanelli and Beyer, 1974)	15
Mouse	—	—	53 (30–78) (Wu et al., 1994; So and Thorens, 2010)	17
Rat	—	—	67 (64–70) (Mazzali et al., 2001; Lu et al., 2016)	15
Dog	—	—	18 (Miller et al., 1951)	25
Mean	205 ± 75	58.9 ± 8.3	41 ± 19	16.5 ± 5.3