TABLE 2.

Comparisons of potencies between anxiolytic-like effects (operant-based anticonflict procedure) and measures of sedation in rhesus monkeys

Values are ED₅₀, dose engendering 50% of the maximum effect, mg/kg, i.v. Numbers in parentheses are S.E.M.

Compound	Anticonflict Effectsa	Rest/Sleep Postureb	Observable Ataxiab	Operant Responding–Decreasea	Moderate Sedationb	Deep Sedationb
	ED50, mg/kg, i.v. (S.E.M.)
Alprazolam	0.007 (0.002)	0.028 (0.01)	0.08 (0.03)	0.27 (0.07)	0.31 (0.02)	0.59 (0.11)
Diazepam	0.11 (0.07)	0.71 (0.33)	1.6 (0.11)	1.7 (0.79)	1.8 (0.12)	6.9 (0.91)
Zolpidem	NE	NE	1.1 (0.1)	0.10 (0.03)	NE	5.7 (0.67)
HZ-166	0.80 (0.3)	1.2 (0.15)	NE [30]	NE [30]	NE [30]	NE [30]
MRK-696	0.18 (0.06)	0.27 (0.13)	0.61 (0.28)	NE [3.0]	NE [3.0]	NE [3.0]
TPA-023B	0.031 (0.014)	0.014 (0.003)	NE [1.0]	NE [1.0]	NE [1.0]	NE [1.0]

NE, no effect (maximum dose tested, mg/kg, i.v.).

^aRowlett et al. (2006), Fischer et al. (2010); unpublished.

^bPresent study.