Fig. 2.

Standard least square analysis results in the left rostral middle frontal gyrus. We performed a least squares (LS) regression analysis to study the relationship between lGI, other demographics, and MRI metrics: we modeled the variability of lGI by ODI controlling for age, gender, thickness, NDI, and diagnosis. The interaction of diagnosis with each MRI variable was also examined, in order to assess differences in correlation between DD and TDC. We identified statistically significant (P = .004) model explaining the left rostral middle frontal gyrus lGI with R-squared of 0.57. In particular thickness and gender seemed to be informative, as well as ODI, however the latter only once considering the different diagnosis. In the rostral middle frontal gyrus, lGI and ODI seem to be directly correlated in DD, whereas not correlated or slightly inversely correlated in TDC.