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. 2018 Jul;94(1):743–748. doi: 10.1124/mol.118.111864

Fig. 2.

Fig. 2.

CBD suppresses endogenous CB1 receptor–mediated metabotropic suppression of excitation. (A) mGluR group I agonist DHPG (10 μM) suppresses EPSCs, but this is reversed by treatment with 500 nM CBD. (B) Sample time course showing DHPG response reversed by subsequent cotreatment with CBD. (C) Bar graph shows maximal inhibition due to DSE before CBD and the effect of DHPG (10 μM) when applied after/with CBD (500 nM). (D) Sample time course showing CBD treatment, followed by coapplication of CBD and DHPG. *P < 0.05 by paired t test.