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. 2018 Jul;366(1):46–57. doi: 10.1124/jpet.117.247262

Fig. 1.

Fig. 1.

NOX4−/− mice have reduced trabecular BV but sustained cortical bone mass with EtOH. (A) Micro-CT images of the trabecular compartment (12 μm resolution). (B) Micro-CT-evaluated trabecular bone parameters: fractional BV/TV; trabecular number (Tb.N); trabecular spacing (Tb.Sp). For each group: WT PF, N = 3; WT EtOH, N = 4; NOX4−/− PF, N = 3; NOX4−/− EtOH, N = 5. (C) Micro-CT images of cortical compartment (12 μm resolution). (D) Micro-CT-evaluated cortical bone parameters: cortical thickness (Ct.Th); total area (T.Ar); bone area (B.Ar); medullary area (M.Ar). For each group: WT PF, N = 4; WT EtOH, N = 5; NOX4−/− PF, N = 4; NOX4−/− EtOH, N = 5. Statistical significance was determined with two-way ANOVA; values with different letter superscripts are statistically different from each other (P < 0.05, Student-Newman-Keuls post hoc test; *P = 0.08 for comparison of mean to NOX4−/− PF).