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. 2018 Jul;366(1):46–57. doi: 10.1124/jpet.117.247262

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Fig. 5. — EtOH significantly downregulates targets of the Wnt pathway in vertebral bone. (A) Cyclin D2 (Ccnd2); (B) Frizzled-5 precursor (Fzd5); (C) Frizzled-8 precursor (Fzd8); (D) Beta-catenin (Cttnb1); (E) Wnt-6 (Wnt6); and (F) F-box/WD repeat-containing protein 4 (Fbxw4). Results analyzed by two-way ANOVA, significant main effects are highlighted and in bold (P < 0.05); borderline significant effects (P ≤ 0.10 in bold only). For each group: WT PF, n = 4; WT EtOH, n = 5; NOX4^−/− PF, n = 5; NOX4^−/− EtOH, n = 6.