Table 1.

The timeline of the study

	Intervention period
	Days of antibiotic treatment							Days after antibiotic treatment
	1	2	3	4	5	Every day	n (end of antibiotic treatment)	n+1	n+2	n+3	n+4	n+5	n+6	n+7	Close-out (n+37)
Enrolment
Eligibility assessment	x
Informed consent reception	x
Allocation and randomisation	x
Handing over of study diary	x
Interventions
Multistrain probiotic
Placebo
Data collection
Study diary
Stool tests in case of diarrhoea
Stool microbiota examination	x						x							x	x
Reception of study diary and unused product															x