Table 2.

Comparison of crude and adjusted OR for CKD among types of antipsychotics by conditional logistic regression

Drug used	CKD cases (n=3411)	Controls (n=10 233)	OR (95% CI)	P value	AOR* (95% CI)	P value
No FGA, no SGA	3	17	0.76 (0.22 to 2.59)	0.6570	0.53 (0.13 to 2.21)	0.3857
FGA alone	300	1278	1		1	—
SGA alone	26	102	1.10 (0.70 to 1.72)	0.6920	1.06 (0.65 to 1.74)	0.8068
Combination	3082	8827	1.50 (1.32 to 1.71)	<0.0001	1.28 (1.11 to 1.47)	0.0009

*Adjusted for diabetes mellitus, congestive heart failure, myocardial infarction, stroke, hyperlipidaemia, hypercholesterolaemia, hypertriglyceridaemia, hypertension and obesity.

AOR, adjusted OR; CKD, chronic kidney disease; FGA, first-generation antipsychotic; SGA, second-generation antipsychotic.