Table 3.

Overall cumulative period of using SGAs

Period of SGA use	CKD cases (n=3411)	Controls (n=10 233)	OR (95% CI)	P value	AOR* (95% CI)	P value
Cumulative SGA use
Non-users	303	1304	1		1
0<period≤ 90	177	552	1.38 (1.12 to 1.71)	0.0026	1.20 (0.95 to 1.51)	0.1247
90<period≤ 180	92	241	1.65 (1.26 to 2.16)	0.0003	1.42 (1.06 to 1.91)	0.0208
180<period≤ 1000	409	1271	1.39 (1.17 to 1.64)	0.0001	1.19 (0.99 to 1.43)	0.0654
1000>period	2430	6865	1.53 (1.34 to 1.75)	<0.0001	1.30 (1.13 to 1.51)	0.0004
Cumulative clozapine use (days)
Non-users	2318	7215	1		1
0<period≤ 90	183	351	1.63 (1.35 to 1.96)	<0.0001	1.48 (1.20 to 1.81)	0.0002
90<period≤180	49	140	1.09 (0.79 to 1.52)	0.6057	0.91 (0.63 to 1.32)	0.6281
180<period≤1000	178	549	1.01 (0.85 to 1.20)	0.9091	0.94 (0.77 to 1.14)	0.5099
1000>period	683	1978	1.08 (0.98 to 1.19)	0.1456	1.14 (1.02 to 1.27)	0.0181
Cumulative olanzapine use (days)
Non-users	2046	6465	1		1
0<period≤90	396	1018	1.23 (1.09 to 1.40)	0.0012	1.18 (1.02 to 1.35)	0.0225
90<period≤180	156	344	1.44 (1.18 to 1.75)	0.0003	1.37 (1.11 to 1.70)	0.0039
180<period≤1000	401	1038	1.22 (1.08 to 1.39)	0.0017	1.15 (1.00 to 1.32)	0.0561
1000>period	412	1368	0.95 (0.85 to 1.08)	0.4401	1.05 (0.92 to 1.19)	0.4954
Cumulative quetiapine use (days)
Non-users	1669	6198	1		1
0<period≤90	399	967	1.54 (1.35 to 1.75)	<0.0001	1.36 (1.19 to 1.57)	<0.0001
90<period≤180	147	356	1.54 (1.26 to 1.88)	<0.0001	1.27 (1.02 to 1.58)	0.0358
180<period≤1000	534	1180	1.69 (1.50 to 1.89)	<0.0001	1.48 (1.30 to 1.68)	<0.0001
1000>period	662	1532	1.61 (1.45 to 1.79)	<0.0001	1.44 (1.28 to 1.62)	<0.0001
Cumulative zotepine use (days)
Non-users	2292	7375	1		1
0<period≤90	319	743	1.38 (1.20 to 1.59)	<0.0001	1.26 (1.08 to 1.47)	0.0038
90<period≤180	120	265	1.46 (1.17 to 1.82)	0.0008	1.27 (0.99 to 1.63)	0.0592
180<period≤1000	310	770	1.30 (1.13 to 1.49)	0.0003	1.16 (1.00 to 1.36)	0.0572
1000>period	370	1080	1.11 (0.97 to 1.26)	0.1240	1.00 (0.87 to 1.15)	0.9854
Cumulative risperidone use (days)
Non-users	896	3056	1		1
0<period≤90	396	1078	1.26 (1.09 to 1.44)	0.0012	1.14 (0.98 to 1.33)	0.0927
90<period≤180	207	511	1.39 (1.16 to 1.66)	0.0003	1.26 (1.03 to 1.53)	0.0220
180<period≤1000	733	2028	1.24 (1.10 to 1.38)	0.0002	1.12 (0.99 to 1.26)	0.0845
1000<period	1179	3560	1.13 (1.03 to 1.25)	0.0148	1.10 (0.99 to 1.23)	0.0756

*Adjusted for diabetes mellitus, congestive heart failure, myocardial infarction, stroke, hyperlipidaemia, hypercholesterolaemia, hypertriglyceridaemia, hypertension and obesity.

AOR, adjusted OR; CKD chronic kidney disease; SGA, second-generation antipsychotic.