Table 1.

SPIRIT flow chart for Trial23

Study period
	Enrolment/ allocation	Postallocation			Close-out
		Baseline screen	Second screen	Third screen
Timepoint	January 2017*	February 2017–September 2018	January 2020–September 2021	January 2023– September 2024	1 October 2025†
Enrolment
Eligibility	X
Allocation	X
Intervention
HPV arm (CYT+HPV)		<—>	<—>‡	<—>
Present programme arm (CYT)		<—>	<—>	<—>
Assessment
Baseline screen		X
Second screen			X
Third screen				X
Final					X

*All women born in 1994 living in Denmark in January 2017 were randomly allocated to HPV or present programme arm.

†End-of-study allowing for 1 year extra for women followed up due to abnormal cytology in former screening rounds.

‡Women with positive HPV test and normal cytology at baseline are retested after 3 years for both HPV and cytology.

CYT, cytology; HPV, human papillomavirus; SPIRIT, Standard Protocol Items: Recommendations for Interventional Trials.