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. Author manuscript; available in PMC: 2018 Jun 5.
Published in final edited form as: Biochem J. 2018 Jan 11;475(1):273–288. doi: 10.1042/BCJ20170702

Figure 2. General mechanism for class D β-lactamases.

Figure 2

Class D carbapenemases like OXA-239 use an active site serine to attack the carbonyl carbon on the β-lactam ring, resulting in the drug forming an acyl-intermediate with the serine. This intermediate is subsequently hydrolyzed to release the inactive drug with a broken β-lactam ring.