Table 2. Antiviral activity of the rhodanine derivatives on Vero cell line infected with HSV-2.
| Compound | HSV-2 | Citotoxicity (Vero cells) | SI | |
|---|---|---|---|---|
| EC50 (nM) | EC90 (nM) | CC50 (μM) | ||
| 1 | 168±143 | 2107±918 | 224.2±78.5 | 1134 |
| 2 | 11.9±5.73 | 481±299 | 111.9±11.6 | 9403 |
| 9a | 345±168 | 426±56.3 | >300 | >869 |
| 9b | 4.89±1.59 | 57.8±22.6 | 10.8±.9.50 | 2209 |
| 9c | 52.0±21.2 | 422±225 | 204.7±30.1 | 3936 |
| 9d | 28.7±7.11 | 140±61.2 | 16.92±4.31 | 604.3 |
| 9e | 50.3±10.5 | 206±85.5 | >100 | >1988 |
| 9f | 26.4±11.1 | 153±159 | 7.87±2.98 | 298 |
| ACV | 622±21.1 | - | 732±46.2 | 1177 |
Acyclovir (ACV) was used as reference compound. Values represent mean±S.D of two independent experiments. EC50 = Half maximal effective concentration. EC90 = 90% maximal effective concentration. CC50 = Half maximal cytotoxic concentration. The selectivity index (SI) was calculated by dividing the CC50 by the EC50 value.