Table 4. Results of in vitro ADME analysis for selected rhodanine derivatives.
| Compound | In vitro ADME | ||||
|---|---|---|---|---|---|
| Water Solub. (μg/mL) | Papp (1·10-6cm/sec) | Metabolic Stability (%) | Kd HSA (μM) | Kd BSA (μM) | |
| 1 | 0.88±0.10 | 1.28 | >90% | 0.63±0.1 | 0.68±0.1 |
| 2 | 0.52±0.13 | 1.26 | >90% | 0.96±0.1 | 0.63±0.1 |
| 9a | 0.54±0.08 | 0.4 | >90% | 1.51±0.2 | 1.08±0.2 |
| 9b | 0.10±0.08 | 2.32 | >90% | 1.57±0.2 | 1.55±0.3 |
| 9c | 0.30±0.07 | 1.23 | >90% | 1.19±0.1 | 1.05±0.1 |
| 9d | 0.25±0.09 | 1.50 | >90% | 1.09±0.9 | 0.99±0.9 |
| 9e | 0.72±0.12 | 0.92 | >90% | 2.19±1.0 | 1.07±0.9 |
| 9f | 0.73±0.14 | 0.87 | >90% | 2.23±1.2 | 1.09±0.9 |
Values represent mean±S.D of three independent experiments