Fig 1. Caspase-1 and caspase-11 are protective in melioidosis.

(A) Mice were infected intranasaly with B. thailandensis (10⁵ CFU) and their survival and body weight were monitored. (B, C) Mice infected with B. thailandensis (5x10⁵ CFU) were sacrificed 48 hours p.i. and the bacterial burden in organs and cytokines in BALF and serum were measured. (D, E) Mice infected intranasaly with B. thailandensis (10⁵ CFU) were sacrificed at the shown time points and cytokine levels and cellular infiltrates in BALF were measured. One representative experiment of three (A-C) or two (D, E) is shown. Data are expressed as mean ± S.D. *p<0.05, **p<0.01, ***p<0.001. (A) log rank Kaplan-Meier test, (B) Mann-Whitney U test, (C) Unpaired t-test, (D, E) One-way ANOVA.