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. 2018 Jun 5;13(6):e0198395. doi: 10.1371/journal.pone.0198395

Fig 5. Definition of the 2 ROIs and the olfactory fMRI responses in these ROIs before and after MK801 injection.

Fig 5

(A) The color-encoded ROIs were superimposed on the 3 consecutive axial gradient-echo EPI images. Purple: olfactory bulb (OB); red: piriform cortex (PC). (B & C) Olfactory response in the OB and PC in the different 1-h periods of 4-h experiment session (mean ± SD, n = 4). Red bars: 1-min odor stimulation. In the OB (B), robust olfactory fMRI response was observed before MK801 injection, and MK801 increased the response. In the PC (C), no robust olfactory response was observed before MK801 injection. After MK801 injection, robust and repeatable olfactory responses were observed. (D & E) Strengths of the olfactory responses during the 4-h experimental session (mean ± SD, n = 4). MK801 increased the response amplitudes in the OB and PC. The asterisks ‘*’ indicate that the strengths of response were significantly larger than the strengths during the first hour before MK801 delivery (paired t-test, all p<0.04).