Skip to main content
. Author manuscript; available in PMC: 2018 Aug 7.
Published in final edited form as: Nature. 2018 Feb 7;554(7691):202–206. doi: 10.1038/nature25462

Figure 2. Adaptors recruit different number of dyneins to dynactin.

Figure 2

a, Kymographs of dynein/dynactin with BICD2 (DDB), BICDR1 (DDR) or HOOK3 (DDH). Moving complexes contain TMR-dynein (magenta), Alexa647-dynein (green) or both (white, white arrowheads). Two independent repeats (>3 replicates/repeat). b, The mean percentage (±s.e.m.) of complexes containing both TMR- and Alexa647-dynein (NDynein=7793, NDDB=3092, NDDR=3107, NDDH=3990; ANOVA with Tukey’s test; ****P<0.0001; n.s. - not significant, P=0.4010). c, Representative negative-stain EM 3D classes of one- and two-dynein complexes for TDB, TDR and TDH. Mean (±s.e.m.) fraction of particles in each class shown. Ambiguous classes are not shown.