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. Author manuscript; available in PMC: 2018 Aug 7.
Published in final edited form as: Nature. 2018 Feb 7;554(7691):202–206. doi: 10.1038/nature25462

Figure 5. Interactions recruiting two dyneins to the TDR complex.

Figure 5

a, Dynein HC (blue/pink) interactions with dynactin subunits (green). Contact residues on dynactin shown as yellow spheres. For each HC, helix α6 is highlighted (dark blue/dark red). b, Dynein-A2 makes extensive interactions with dynein-B1. Interaction sites shown as yellow and red spheres. c, Interactions of dynein-A (top) and dynein-B1 (bottom) with BICDR1. Interaction sites marked in dark blue and red. Extra density, from dynein-A2 LIC, mediates the connection between dynein-B1 and BICDR1. d, Negative-stain EM reconstructions of DDB containing two dyneins (top) or only dynein-A (bottom), sliced to highlight BICD2. Arrows depict alternative positions of BICD2 at dynactin’s barbed end.