Extended Data Figure 6. Interactions between dynein subunits.

a, The dynein HC (yellow) interacts with the IC WD40 domain (blue) using bundle 4 and 5, with a helical segment (red cartoon) sitting in the WD40 central cavity. Interacting residues are shown as sticks (bottom panel) with HC residues in red, and IC residues in green. b, Density map and model showing how the LIC (density and cartoon, blue) N- and C-terminal regions extend from the globular domain and pack against the HC (density, colored by bundle number). c, Robl (cartoon, light and dark pink) makes contacts to the IC N-terminal helices (cartoon, light and dark blue), which mediate the interaction between Robl and the IC WD40 (surface). d, Representative density from the 1.9 Å resolution N-terminal dimerization domain (NDD) crystal structure. e, Cartoon model of the NDD showing one chain in rainbow spectrum.