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. Author manuscript; available in PMC: 2018 Jun 5.
Published in final edited form as: Sci Signal. 2017 Nov 7;10(504):eaan0852. doi: 10.1126/scisignal.aan0852

Fig. 2. Rac1 signaling is increased in the somatosensory cortex of FXS mice.

Fig. 2

(A to E) Representative Western blotting of proteins in the Rac1 signaling pathway in somatosensory lysates (A) or synaptosomes (B to E) from 1-week-old male WT and Fmr1 KO mice (WT, n = 4 to 12;KO, n = 4 to 15). Data are means ± SEM. *P < 0.05, ****P <0.0001. (F) Model depicting a mechanism by which loss of FMRP leads to increased Rac1 signaling, cofilin phosphorylation (a measure of inactivation), and actin polymerization.