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. Author manuscript; available in PMC: 2018 Jun 5.
Published in final edited form as: Sci Signal. 2017 Nov 7;10(504):eaan0852. doi: 10.1126/scisignal.aan0852

Fig. 6. Inhibition of PAK corrects impaired sensory processing in FXS model mice.

Fig. 6

(A) Timeline of the whisker-dependent texture discrimination task. (B) Discrimination of a novel versus familiar texture in WT and Fmr1 KO mice, as assessed by a preference index at chance level indicating impaired sensory processing (WT, n = 13; KO, n = 7). (C and D) Discrimination of a novel texture versus a familiar texture WT mice subjected to (C) whisker trimming (n = 10 animals) or (D) a texture-less object (n = 7 animals), indicating the necessity for an intact mystacial vibrissae to discriminate textures. (E) Novel object recognition task in WT and Fmr1 KO mice (WT, n = 7; KO, n = 8 animals). (F) Sensory processing, as assessed by the ability to discriminate a novel texture versus a familiar texture, in Fmr1 KO animals subjected to chronic administration of FRAX486 (once at P7, once at P14, and once at 3 to 4 weeks of age 24 hours before testing) (WT vehicle, n = 15; KO vehicle, n = 9; WT FRAX486, n = 10;KO FRAX486, n =10). Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.