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. Author manuscript; available in PMC: 2018 Jun 5.
Published in final edited form as: J Alzheimers Dis. 2018;62(1):347–359. doi: 10.3233/JAD-170617

Fig. 2.

Fig. 2

Active PERK levels are present in 3mo Ts65Dn mice brains. A) Representative western blot showing increased GRP78 and pPERK (pT981). B) Quantification of panel A showing significantly increased GRP78 levels in Ts65Dn brains. C) Quantification of panel A showing levels of pPERK, PERK, and the pPERK to total PERK ratio. Densitometric values shown in the bar graph are the mean of 6 samples per each group normalized per total load and are given as percentage of Euploid mice, set as 100%. Statistical significance was determined using Student t-test analysis (*p < 0.05, **p < 0.01).