Table 3.
Fold increase values for RT-PCR
| Gene | Single age comparison | Age dependent comparison | |||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Ratio Ts65Dn:Eu | 9mo:3mo | 18mo:3mo | |||||
|
|
|
|
|||||
| 3mo | 9mo | 18mo | Eu | Ts65Dn | Eu | Ts65Dn | |
| HSPA5 | 0.30* | 0.04 | –0.04 | 1.22** | 0.68 | 0.57* | 0.42* |
| EIF2AK3 | 0.31* | −0.02 | –0.22* | 0.39 | –0.25* | 0.69** | –0.08 |
| ATF6 | 0.09 | −0.05 | –0.04 | 0.07 | 0.03 | 0.13 | 0.21 |
| ERN1 | –0.02 | −0.39 | –0.39* | 0.58 | –0.18 | 0.70* | –0.27 |
| EIF2A | 0.31* | −0.16 | –0.21* | 0.61* | 0.01 | 0.54** | –0.18 |
| PPP1R15A | –0.18 | −0.20 | –0.15 | 0.10 | –0.03 | 0.10 | –0.04 |
| ATF4 | 0.20 | −0.33* | –0.41* | 0.31 | –0.29* | 0.55* | –0.18* |
| DDIT3 | –0.15 | −0.25 | –0.2 | 0.56* | –0.07 | 0.37* | –0.27* |
Statistical significance was determined using Student t-test analysis (*p < 0.05, **p < 0.01).