Table 2.
Diagnostic performance of biomarker models of microalbuminuria (ACR ≥3 mg/mmol), eGFR < 60 mL/min/1.73m2 and CKD compared to gold standard ACR and eGFR tests in type 2 diabetes.
| Diagnostic Test | Diagnosis | AUC | True Positive Rate (Sensitivity) | False Positive Rate (1-Specificity) |
DOR | |
|---|---|---|---|---|---|---|
| Gold Standard ACR | eGFR < 60 mL/min/1.73m2 | N/A | 73% | 40% | 4.0 | |
| Gold Standard eGFR | ACR ≥ 3 mg/mmol | N/A | 26% | 8% | 4.0 | |
| TRAIN (n = 459) | BM (eGFR model)a | eGFR < 60 mL/min/1.73m2 | 0.80 | 73% | 25% | 8.3 |
| BM (ACR model)a | ACR ≥ 3 mg/mmol | 0.68 | 72% | 42% | 3.6 | |
| BM (CKD model)a | CKD ≥ 1 | 0.68 | 56% | 25% | 3.9 | |
| TEST (n = 113) | BM (eGFR model)a | eGFR < 60 mL/min/1.73m2 | 0.81 | 88% | 32% | 14.9 |
| BM (ACR model)a | ACR ≥ 3 mg/mmol | 0.71 | 52% | 15% | 6.0 | |
| BM (CKD model)a | CKD ≥ 1 | 0.77 | 56% | 15% | 7.6 | |
The performance of the models in the train and test sub-cohorts is shown.
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-BM (eGFR model) (APOA4_Pep 2, APOC3_Pep 1, CFHR2_Pep 1, IBP3_Pep 2).
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-BM (ACR model) (APOA4_Pep 1, C1QB_Pep 1, CFHR2_Pep 2, IBP3_Pep 2).
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-BM (CKD model) (APOA4_Pep 1, CFHR2_Pep 2, IBP3_Pep 2).
a
BM, Biomarker model; AUC, area under curve; DOR, diagnostic odds ratio. BM models were developed in train sub-cohort and validated in test sub-cohort.