Fig. 2.

Signal transduction diagram that connects two most significant common regulators (light red nodes at the top of the diagram) and TFs (light blue nodes in the middle and at the bottom of the diagram) whose sites found overrepresented in the promoters of differentially expressed genes. Red, blue and gray decoration of the odes in the diagram annotates the phosphorylation of the respective proteins detected in the phosphoproteomics experiment. The left part of the decoration circle corresponds to the protein phosporialytion observed in the cytoplasm of the cells and the right side corresponds to the protein phosphorylation observed in the nucleus. The red color of the decoration corresponds to the increased level of phosphorialtion after treatment of cells by RA, blue color corresponds to decreased level and gray – the same level of phosphorylation of these proteins after the RA treatment.