Table 5.

Statistically significant common regulators found by the graph algorithm of the geneXplain platform (www.genexplain.com) by searching upstream of TFs listed in Table 5 in the signal transduction network of TRANSPATH database [38]. TF-reached—number of TFs (out of 12 from Table 5) that are reached in the network downstream from the respective common regulator; Score—score of the common regulator calculated on the basis of the number of reached TFs and topology of the network [28]; FDR and Z-score are calculated by multiple randomization of input set of TFs [28].(FDR <0.05 AND Z-Score > 1.0 AND TF-reached > 7).

TRANSPATH ID	Name of common regulator	TF reached	Score	FDR	Z-Score	Phospho Cytoplasm	Phospho Nucleus
MO000056714	HDAC1	8	0.623	0.036	1.031	p-up	p-up
MO000257368	SUSP1	8	0.555	0.031	1.354	p	p-dn
MO000103308	CKI-gamma1	8	0.530	0.035	1.093
MO000019363	RelA-p65	7	0.484	0.030	1.679	p	P
MO000132731	PP4C	7	0.445	0.047	1.068	p	P
MO000140900	ing4	8	0.434	0.050	1.613
MO000272358	ctcf{sumo}	7	0.390	0.035	1.455	p	P
MO000284804	RNF96{p}	7	0.341	0.047	1.590	p-up	p-dn
MO000107711	RXR-alpha{sumo}	8	0.337	0.033	1.549	p	P
MO000272357	ctcf{sumo}	7	0.275	0.049	1.564	p	P
MO000284833	RNF96{pS473}{pS824}	7	0.250	0.040	1.833	p-up	p-dn