Fig. 2.

A part of the predicted signal transduction network of MTX-resistant colorectal cancer cells that is reconstructed with the help of the master-regulator search algorithm implemented in the geneXplain platform. Transcription factors (blue) are shown at the bottom and in the center. Potential master regulators (pink) are shown at the top. The direction of signal flow is from top to bottom. Intermediary molecules are green. Gray half-circles indicate proteins identified by the proteomics experiment in HT29 cell line. Yellow half-circles indicate proteins encoded by genes up-regulated in MTX-resistant cells.