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Estrogen signaling pathway regulates RASD1 expression in uterine epithelium of control and RIF patients. In normal uterine endometrium, estrogen signals are transduced via the non-genomic action of estrogen receptor, which mediates the RAS/MEK/ERK pathway to regulate RASD1 expression for successful implantation. In RIF endometrium, decreased estrogen expression result in a reduction in the levels of RASD1 factors.
