Table 6.
Combine effect of ApoE genotype and T2DM on serum parameters and cognition in aging Chinese subjects.
| Serum parameters and cognition | ApoE2 (n=134) | ApoE3 (n=673) | ApoE4 (n=145) | P value | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| nT2DM (n=105) | T2DM (n=29) |
nT2DM (n=497) | T2DM (n=176) |
nT2DM (n=112) | T2DM (n=33) |
||
| Serum parameter (mmol/L) | |||||||
| Glu | 5.5 (5.2, 5.9) | 7.3 (6.7, 7.9) | 5.4 (5.2, 5.5) | 7.2 (7.0, 7.5) | 5.2 (4.9, 5.6) | 7.3 (6.7, 8.0) | 0.30 |
| TC | 5.2 (4.9, 5.4) | 5.0 (4.6, 5.4) | 5.0 (4.9, 5.1) | 4.9 (4.7, 5.1) | 5.2 (5.0, 5.4) | 5.0 (4.6, 5.4) | 0.97 |
| TG | 2.2 (1.9, 2.5) | 2.6 (2.0, 3.07) | 1.7 (1.5, 1.8) | 1.9 (1.6, 2.1) | 1.8 (1.5, 2.0) | 2.6 (2.1, 3.1) | 0.21 |
| LDL-C | 2.9 (2.7, 3.1) | 2.9 (2.6, 3.3) | 3.2 (3.1, 3.3) | 3.2 (3.1, 3.3) | 3.3 (3.1, 3.5) | 3.1 (2.8, 3.4) | 0.55 |
| HDL-C | 1.5 (1.4, 1.6) | 1.3 (1.1, 1.4) | 1.4 (1.3, 1.4) | 1.3 (1.3, 1.4) | 1.4 (1.4, 1.5) | 1.2 (1.1, 1.3) | 0.05 |
| Cognition | |||||||
| Visual & executive | 3.8 (3.6, 4.1) | 3.6 (3.2, 4.1) | 3.9 (3.8, 4.0) | 4.0 (3.8, 4.1) | 4.0 (3.7, 4.2) | 3.4 (3.0, 3.8) | 0.14 |
| Naming | 2.9 (2.8, 3.0) | 2.9 (2.7, 3.0) | 2.9 (2.9, 3.0) | 2.9 (2.9, 3.0) | 2.8 (2.8, 2.9) | 2.8 (2.6, 2.9) | 0.63 |
| Attention | 5.2 (4.9, 5.4) | 5.5 (5.1, 6.0) | 5.3 (5.2, 5.4) | 5.5 (5.3, 5.6) | 5.4 (5.2, 5.6) | 5.2 (4.8, 5.6) | 0.46 |
| Language | 2.1 (1.9, 2.3) | 2.4 (2.1, 2.7) | 2.2 (2.2, 2.3) | 2.3 (2.1, 2.4) | 2.2 (2.0, 2.3) | 2.0 (1.7, 2.3) | 0.24 |
| Abstraction | 1.6 (1.4, 1.7) | 1.8 (1.5, 2.0) | 1.7 (1.6, 1.7) | 1.7 (1.5, 1.8) | 1.6 (1.5, 1.7) | 1.6 (1.4, 1.8) | 0.64 |
| Memory and delayed recall | 3.1 (2.8, 3.4) | 2.7 (2.2, 3.3) | 3.1 (2.9, 3.2) | 3.2 (3.0, 3.4) | 3.0 (2.7, 3.3) | 3.0 (2.5, 3.5) | 0.42 |
| orientation | 5.8 (5.6, 5.9) | 5.9 (5.6, 6.18) | 5.8 (5.7, 5.9) | 5.9 (5.7, 6.0) | 5.7 (5.6, 5.9) | 5.5 (5.2, 5.8) | 0.48 |
| MoCA score | 24.5 (23.6, 25.4) | 25.3 (23.5, 27.0) | 25.1 (24.7, 25.5) | 25.7 (25.0, 26.4) | 24.9 (24.0, 25.8) | 23.7 (22.1, 25.3) | 0.38 |
Data were expressed as mean (95% CI). Glu, glucose; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride; ApoE, apolipoprotein E; nT2DM-MCI, mild cognitive impairment subjects without type 2 diabetes mellitus; T2DM-MCI, mild cognitive impairment subjects with type 2 diabetes mellitus. General Line Model (GLM) was used for data serum parameters and cognition comparison. Factors including age, BMI, education, smoking, alcohol drinking, exercise, reading habits, housework doing were adjusted. P < 0.05 was considered as significance.