Table 1.
summary of the second neuroprotective strategies combined with hypothermia in ischemic stroke.
| Main Function of combined strategies | Combined strategies | Specified treatment |
|---|---|---|
| Reduce energy consumption | Anesthetics | Methohexital Thiopentone sodium Xenon Dexmedetomidine |
| Psychotropic agents | Chlorpromazine and promethazine | |
| Suppress calcium overload | NMDA receptor antagonists Ryanodine receptor inhibitor |
Dextromethorphan MK-801 Delfotel Magnesium with or without tirilazad Dantrolene |
| Increase blood supply | Reperfusion Vessel dilator Induce arteriogenesis |
t-PA Intra-arterial recanalization Statin Granulocyte colony stimulating factor (G-CSF) |
| Anti-inflammation | Antibiotics | Tacrolimus Minocycline |
| Anti-oxidative stress | Oxidative stress scavengers | Edaravone Mannitol |
| Repair damaged cells | Biosynthesis of cell component | Citicoline |
| Increase oxygen supply | Oxygen | Normobaric oxygen Hyperbaric oxygen |
| Reduce intracranial pressure | - | Decompressive craniectomy |
| Anti-apoptosis | Anti-apoptosis protein | FNK protein |
| Gene of anti-apoptosis protein | Bcl-2 gene | |
| Multiple protection | - | Caffeinol (caffeine and ethanol) Insulin-like growth factor-1 (IGF-1) Brain-derived neurotrophic factor (BDNF) Albumin |