Table 2.

a. Colonic biomarkers:
Symbols	logFC#	adj.P.Val#	logFC*	adj.P.Val*
CEACAM7	7.93	0.001	1.34	0.005
FAM55D	5.17	0.001	0.21	0.095
CA2	5.04	0.043	0.79	0.007
MUC4	4.91	0.011	0.90	0.005
CD24	4.77	0.001	1.59	0.000
IL1R2	4.75	0.006	0.72	0.004
CA4	3.93	0.003	2.20	0.000
CD177	3.77	0.023	0.41	0.050
SFN	3.39	0.020	0.60	0.021
LEFTY1	3.18	0.008	0.45	0.096
ADORA2B	3.10	0.033	0.72	0.000
CA12	3.07	0.015	1.08	0.000
SLC16A1	2.79	0.018	0.38	0.011
FXYD3	2.53	0.025	0.48	0.063

b. Ileal biomarkers
Symbols	logFC#	adj.P.Val#	logFC*	adj.P.Val*
SERPINA1	−2.43	0.028	−0.47	0.012
SLC7A7	−2.60	0.043	−0.65	0.002
SFXN3	−2.73	0.020	−0.66	0.000
PDZK1	−3.11	0.016	−1.01	0.001
ACE2	−3.39	0.024	−0.86	0.000
CCL25	−3.53	0.005	−0.61	0.011
CHRFAM7A	−3.54	0.034	−0.81	0.000
SLC5A1	−3.58	0.018	−0.55	0.010
SI	−3.69	0.014	−0.43	0.087
ABCG5	−3.92	0.041	−1.28	0.000
SLC6A20	−4.21	0.018	−0.47	0.015
GPD1	−4.35	0.001	−0.60	0.001
SLC7A9	−4.39	0.002	−0.83	0.002
KCNJ13	−4.52	0.018	−0.60	0.045
TM4SF4	−4.70	0.047	−2.18	0.000
DPP4	−4.82	0.030	−0.96	0.000
APOB	−4.90	0.011	−1.41	0.000
ENPEP	−4.95	0.017	−0.91	0.003
MAOB	−5.01	0.011	−1.27	0.000
SLC2A2	−5.07	0.015	−0.95	0.001
AADAC	−5.27	0.005	−1.85	0.000
SLC15A1	−5.42	0.019	−0.80	0.000
MTTP	−5.53	0.002	−0.72	0.002
APOC3	−5.59	0.027	−1.35	0.000
CYP3A4	−5.72	0.018	−2.01	0.000
DNASE1	−5.76	0.001	−0.60	0.026
CYBRD1	−5.88	0.020	−0.67	0.004
MME	−6.03	0.003	−1.50	0.000
ALDOB	−6.24	0.005	−0.70	0.008
APOA1	−6.59	0.002	−2.26	0.000
ALPI	−6.60	0.000	−0.72	0.005
APOA4	−6.71	0.003	−1.49	0.000

Colonic biomarkers (Table 2A) or ileal biomarkers (Table 2B) were assembled from Quadrant-1 or 3 genes, respectively in Figure 3A & 3B. Fold changes were determined by normal Colon/Ileum in Comelli’s microarray data

^#or Pouch/pre-pouch in our RNA-seq data

^*Adjusted p-value were computed using R/Bioconductor package 'limma'.