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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Curr Opin Biotechnol. 2017 Dec 7;51:64–69. doi: 10.1016/j.copbio.2017.11.015

Fig. 2. Published specific productivity, cell density and total product titer has improved steadily over the years.

Fig. 2

The trend for three major productivity metrics reported by literature from 2000- 2010 [60]. As a result of development in bioprocessing and feeding strategies, the volumetric yield has been greatly improved. The introduction of cell engineering to CHO has further improved the per-cell productivity since the mid-2000s.