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. 2018 May 16;118(11):1425–1433. doi: 10.1038/s41416-018-0082-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — PD response to AZD1208 treatment in the AML dose-escalation study. The percentage of change from baseline in the reduction of (a) pBAD S112, and (b) p4E-BP1 S65 in bone marrow and peripheral blood samples collected following a single dose of AZD1208 is shown. Only the maximal PD response measured on Day 1 for peripheral blood samples is shown. Each column represents an individual patient, with adjacent columns corresponding with matched marrow and blood samples. AML, acute myeloid leukaemia; PD, pharmacodynamics