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. 2018 Jun 5;8:8595. doi: 10.1038/s41598-018-26814-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neither treatment nor genotype significantly altered short-term spatial reference memory in the Morris water maze assay. (a) Learning curve of platform location, two-way ANOVA with repeated measures followed by Holm-Sidak’s post hoc test, P > 0.05, n = 12 (C/HT, IF/HT), 15 (C/WT) and 16 (IF/WT); (b) total distance travelled, two-way ANOVA followed by Holm-Sidak’s post hoc test, P > 0.05, n = 11 (IF/HT), 12 (C/HT), 14 (C/WT) and 16 (IF/WT); (c) mean swimming speed, two-way ANOVA followed by Holm-Sidak’s post hoc test, P > 0.05, n = 11 (IF/HT), 12 (C/HT), 14 (C/WT) and 16 (IF/WT); (d) distance travelled in each quadrant of the Morris water maze, one-way ANOVA, ^*P ≤ 0.001, n = 12 (C/HT, IF/HT), 15 (C/WT) and 16 (IF/WT); (e) time spent in target quadrant, two-way ANOVA followed by Holm-Sidak’s post hoc test, P > 0.05, n = 11 (IF/HT), 12 (C/HT), 14 (C/WT) and 16 (IF/WT); (f) mean distance from platform area, two-way ANOVA followed by Holm-Sidak’s post hoc test, P > 0.05, n = 11 (IF/HT), 12 (C/HT), 14 (C/WT) and 16 (IF/WT).