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. 2018 Jun 5;8:8652. doi: 10.1038/s41598-018-26984-3

Figure 3.

Figure 3

GM-CSF neutralization during M. tuberculosis infection. WT or TNFα−/− mice infected with M. tuberculosis H37Rv (1000 ± 200 CFU/mouse i.n.) received either GM-CSF neutralizing MAB (Clone A7.39, 200 µg per mouse i.p.) or IgG2b isotype control on day 14 and 21 post-infection and relative body weight gain was recorded (A,C). Bacterial burden was determined in the lungs on day 26 for TNFα−/− mice and on day 32 for WT mice (B,D). Data are from two independent experiments (n = 5–9 mice per group) and are expressed as mean values ± SEM. No statistical difference between the groups were observed (p > 0.05).