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. 2018 Jun 5;8:8637. doi: 10.1038/s41598-018-26882-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HFD with NAM induces hepatomegaly and liver fibrosis in male NNMT Tg mice. (A,B) After 3 months of HFD feeding, mice were treated with NAM. Body weight, food consumption, and food efficiency after administration of a NAM-supplemented HFD for 7 months in NMMT Tg mice (black bars) and WT littermates (white bars) (n = 5–8 per group) were measured. (C) Mouse abdominal cavity demonstrating hepatomegaly in Tg mice. Epididymal and inguinal fat weight/body weight ratios in Tg and WT mice (n = 5–6 per group) after being fed a NAM-supplemented HFD for 7 months. (D) Histology of epididymal adipose tissue in mice on an HFD with NAM. Mean adipocyte size in Tg versus WT mice (n = 4/group). (E) The bar graph shows the liver weight/body weight ratio and serum levels of AST and ALT, after being fed an HFD with NAM, in Tg and WT mice (n = 5–6 per group). Liver triglyceride content in Tg and WT mice after high-fat diet (n = 5–6 per group). (F) H-E staining (upper panel) and Masson trichrome staining (lower panel) of liver from Tg and WT mice fed an HFD with NAM for 7 months. Bars represent 1.0 mm. NAFLD activity score and Masson trichrome stained blue area (%) were assessed (n = 5–6 per group). *P < 0.05, **P < 0.01 versus WT mice. Abbreviations: NAM, nicotinamide; NNMT, nicotinamide N-methyltransferase; HFD, high fat diet; Tg, transgenic; WT, wild type.