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. 2018 Jun 5;8:8637. doi: 10.1038/s41598-018-26882-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NNMT Tg mice have improved lipid metabolism. (A) Fasting blood glucose levels of NMMT Tg mice and WT littermates fed a NAM-supplemented HFD for 7 months (n = 6–9 per group). (B) Glucose tolerance testing and the area under the curve (AUC) for glucose in Tg and WT mice (n = 5–8 per group). Plasma triglyceride (C) and total cholesterol (D) concentrations were determined in fasted Tg and WT mice (n = 5–6 per genotype). (E) Lipoprotein profiles of plasma triglycerides (left panel) and cholesterol (right panel), after fasting (n = 4 per genotype). (F) Triglyceride concentrations following triton injection in fasted Tg and WT mice (n = 6–9 per group). *P < 0.05, **P < 0.01 versus WT mice. Abbreviations: NAM, nicotinamide; NNMT, nicotinamide N-methyltransferase; HFD, high fat diet; Tg, transgenic; WT, wild type.