Figure 2.

Increased S. ratti parasite burden in mice with IL-9R^−/− hematopoietic compartment. WT and IL-9R^−/− mice on BALB/c background were lethally irradiated with 8 Gy and received 3 × 10⁶ bone marrow cells from WT or IL-9R^−/− donor mice as indicated. Engraftment was verified by flow cytometry after 8 weeks and chimeras were s.c. infected with 2000 S. ratti L3i. Parasite burden in the small intestine was counted at day 6 p.i. Shown are the combined results of 2 independent experiments n ≥ 3 per group and experiment. Each symbol represents an individual mouse, error bars show SEM and asterisks indicate statistical significant differences between the groups (^*p < 0.05; ^**p < 0.01; Students t-test).