Fig. 6.

Endothelial Akt1 loss promotes invasion of human DU145 prostate cancer cells in vitro. a Representative Images of transwell plates showing DU145 cells successfully invaded through the Matrigel and Akt1-deficient HLEC monolayers alone and after treatment with ICG001 and IWR-1. b Bar graphs showing invaded DU145 cells through Akt1-deficient HLEC monolayers in the presence and absence of treatment with β-catenin inhibitors ICG001 and IWR-1 (n = 6). Data are represented as mean ± SD. *p < 0.05