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. 2018 Apr 26;118(11):1442–1452. doi: 10.1038/s41416-018-0078-x

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© Cancer Research UK 2018

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Fig. 2 — Inhibitory effect in different targets. a Effect of IL-6R/IL-6R inhibition by Dia on MAO-A activity by western blot analysis. b Effect of IL-6/IL-6R inhibition by Dia treatment in hypoxic breast cancer cells on MAO-A activities. MAO-A expression was highly up-regulated due to inhibition of IL-6. c Cells were treated with CoCl2 and siRNA IL-6R transfection or Dia treatment was performed in hypoxic breast cancer cells. MAO-A and HIF-1α expression was shown. d Western blot using STAT3 inhibitor (PF-04965842) in dose dependent manner. e Western blot using AG126, a specific inhibitor of MAPK. f Western blot using LY294002, a specific PI3K/Akt inhibitor