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. 2018 Jan 23;25(6):1160–1173. doi: 10.1038/s41418-017-0034-y

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© ADMC Associazione Differenziamento e Morte Cellulare 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PGAM1 expression correlates with mTOR signaling in tumor tissues and patient prognosis of human NSCLC. a IHC analysis of 227 paraffin-embedded human NSCLC tumors including adenocarcinomas (ADCs), squamous cell carcinomas (SCCs), and large-cell lung cancer (LCLC) (× 200) for the abundance of PGAM1 and pS6 (Ser235/236). Representative pictures of high and low expression were shown. b, c Kaplan–Meier survival curves illustrate the overall survival (OS, left) and progression-free survival (PFS, right) of NSCLC patients in respect to the expressions of PGAM1 b and pS6 c. d Schematic illustration of mTOR regulation of PGAM1, aerobic glycolysis, and tumorigenesis